Endocrine Abstracts

Context: Risk stratification for persistent disease is an important step in pediatric differentiated thyroid cancer (DTC) management. The dynamic risk stratification (DRS) is a well validated system for adults, but not yet for children and adolescents.Objective: To evaluate DRS performance and other prognostic factors in pediatric DTC.Design: Cohort study.Setting: Four DTC referral centers at tertiary teachin...

Background: At a preplanned interim analysis (median follow-up 6.2 months) of the double-blind, phase 3 COSMIC-311 trial (NCT03690388), cabozantinib significantly improved progression-free survival (PFS) vs placebo (HR 0.22, 96% CI 0.13-0.36; P<0.0001) in 187 patients with previously treated radioiodine-refractory DTC (Brose, Lancet Oncol; 2021). Patients must have received lenvatinib or sorafenib and progressed during or after 1-2 prior VEGFR inhibitors. We prese...

Background: Increasing age is associated with poorer survival in DTC [Oyer SL, 2012]. In the phase 3 COSMIC-311 trial (NCT03690388), cabozantinib, an inhibitor of VEGFR2, MET, AXL and RET, significantly improved the progression-free survival (PFS) vs placebo in previously treated patients with RAI-R DTC (HR 0.22, 96% CI 0.13-0.36; P<0.0001; median follow-up 6.2 months). The impact of age on efficacy and safety was included in the prespecified subgroup analysis.</p...

Iodine is a trace element required for thyroid hormone production. Requirements increase in pregnancy, when even mild deficiency may affect offspring neurocognitive development.The gold standard for assessing iodine status is population surveys of urinary iodine concentration (UIC). The WHO also suggests a population prevalence of >3% of TSH values > 5 mIU/L indicates deficiency. A recent UK survey of 700 teenage girls demonstrated ...

Iodine is a trace element required for thyroid hormone production. Requirements increase in pregnancy, when even mild deficiency may affect offspring neurocognitive development.The gold standard for assessing iodine status is population surveys of urinary iodine concentration (UIC). The WHO also suggests a population prevalence of >3% of TSH values > 5 mIU/L indicates deficiency. A recent UK survey of 700 teenage girls demonstrated ...

Objectives: RET alterations are targetable oncogenic drivers in TC. Patients with TC, especially those with MTC treated with the multikinase inhibitors cabozantinib and/or vandetanib (C/V), often experience significant treatment-related side effects. Pralsetinib, a selective RET tyrosine kinase inhibitor, showed efficacy in patients with RET-altered TC from the phase 1/2 ARROW trial (NCT03037385). We present the impact of pralsetinib on PROs in patients with ...

Introduction: Diabetic nephropathy is the main global cause of end stage renal disease. According to the annual report from the Portuguese National Diabetes Observatory, in 2013, the prevalence of diabetes mellitus (DM) in new cases of chronic kidney disease was 31.2 and 11.1% in kidney transplant patients.Aim: To characterise the population of type 2 diabetic patients admitted in diabetes and kidney transplant consult (DKTC), comparing those admitted be...

In spite of achievements in diabetology on insulinotherapy optimization, the number of patients with T1DM, who do not achieve target indicators of compensation, remains to be high.Objective: To estimate compensation and frequency of self-control carrying out among patients with T1DM in Belarus.Materials and methods: Total 965 patients with T1DM (467m, 498f), mean age (M±m) 34.33±0.51 years (1.80–72.75), age of T1D ma...

Our research focused on the role of immune mechanisms in diabetic foot ulcers development and impaired healing. The AIM of this study was to evaluate endogenous interleukin (IL1,4,6,8) production to the culture medium by the skin cells (keratinocytes and fibroblasts) cocultured with mononuclears of patients with type 2 diabetes mellitus (T2DM) and T2DM with chronic foot ulcers (DFU) in a 3D culture model.Materials and methods: A multilayer 3D immunocompe...

Introduction: The main purpose of this case is to present a case in which the left kurtosis interval of the fertile phase curve, may be evaluated by cheeking the biophysical changing pattern of reproducible methods of viscoelasticity and transparency of the cervical secretion.Case report: This case report included a 24 years old woman who plots a curve in which integrates two biomarkers in relation to the fertile window at the follicular phase. It was re...